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Page 1
Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease.
Allen IC, Pace AJ, Jania LA, Ledford JG, Latour AM, Snouwaert JN, Bernier V, Stocco R, Therien AG, Koller BH. Allen IC, et al. Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1005-17. doi: 10.1152/ajplung.00174.2006. Epub 2006 Jul 7. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16829631 Free article.
The expression of the protein GPRA (G protein-coupled receptor for asthma susceptibility) in human airway epithelia and smooth muscle, and its increased expression in a mouse model of asthma, suggested that a gain-of-function mutation in this gene increased the disease ris …
The expression of the protein GPRA (G protein-coupled receptor for asthma susceptibility) in human airway epithelia and smooth muscle, and i …
Mutant β1-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy.
Dong Q, Ptáček LJ, Fu YH. Dong Q, et al. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2221686120. doi: 10.1073/pnas.2221686120. Epub 2023 Apr 4. Proc Natl Acad Sci U S A. 2023. PMID: 37014857 Free PMC article.
We recently demonstrated that two familial natural short sleep (FNSS) mutations, DEC2-P384R and Npsr1-Y206H, are strong genetic modifiers of tauopathy in PS19 mice, a model of tauopathy. ...
We recently demonstrated that two familial natural short sleep (FNSS) mutations, DEC2-P384R and Npsr1-Y206H, are strong genetic modif …
G protein-coupled receptor mutations and human genetic disease.
Thompson MD, Hendy GN, Percy ME, Bichet DG, Cole DE. Thompson MD, et al. Methods Mol Biol. 2014;1175:153-87. doi: 10.1007/978-1-4939-0956-8_8. Methods Mol Biol. 2014. PMID: 25150870 Review.
Genetic variations in G protein-coupled receptor genes (GPCRs) disrupt GPCR function in a wide variety of human genetic diseases. In vitro strategies and animal models have been used to identify the molecular pathologies underlying naturally occurring GPCR mutations …
Genetic variations in G protein-coupled receptor genes (GPCRs) disrupt GPCR function in a wide variety of human genetic diseases. In vitro s …
The protective effect of farm animal exposure on childhood allergy is modified by NPSR1 polymorphisms.
Bruce S, Nyberg F, Melén E, James A, Pulkkinen V, Orsmark-Pietras C, Bergström A, Dahlén B, Wickman M, von Mutius E, Doekes G, Lauener R, Riedler J, Eder W, van Hage M, Pershagen G, Scheynius A, Kere J. Bruce S, et al. J Med Genet. 2009 Mar;46(3):159-67. doi: 10.1136/jmg.2007.055137. Epub 2008 Feb 19. J Med Genet. 2009. PMID: 18285428 Free article.
In response to LPS, NPSR1-A protein levels in monocytes were upregulated (p = 0.002), as were NPSR1-A mRNA levels (p = 0.02). CONCLUSIONS: The effect of farm animal contact on the development of allergic symptoms in children is modified by NPSR1 geneti …
In response to LPS, NPSR1-A protein levels in monocytes were upregulated (p = 0.002), as were NPSR1-A mRNA levels (p = 0.02). …
Neuropeptide S counteracts 6-OHDA-induced motor deficits in mice.
Didonet JJ, Cavalcante JC, Souza Lde S, Costa MS, André E, Soares-Rachetti Vde P, Guerrini R, Calo' G, Gavioli EC. Didonet JJ, et al. Behav Brain Res. 2014 Jun 1;266:29-36. doi: 10.1016/j.bbr.2014.03.002. Epub 2014 Mar 11. Behav Brain Res. 2014. PMID: 24613977
Based on the close relationship between dopamine and Parkinson disease (PD) and on the evidence that NPSR are expressed on brain dopaminergic nuclei, the present study investigated the effects of NPS in motor deficits induced by intracerebroventricular (icv) administration …
Based on the close relationship between dopamine and Parkinson disease (PD) and on the evidence that NPSR are expressed on brain dopa …
A new mouse model for mania shares genetic correlates with human bipolar disorder.
Saul MC, Gessay GM, Gammie SC. Saul MC, et al. PLoS One. 2012;7(6):e38128. doi: 10.1371/journal.pone.0038128. Epub 2012 Jun 4. PLoS One. 2012. PMID: 22675514 Free PMC article.
Bipolar disorder (BPD) is a debilitating heritable psychiatric disorder. Contemporary rodent models for the manic pole of BPD have primarily utilized either single locus transgenics or treatment with psychostimulants. ...We found dysregulation of multiple transcripts whose …
Bipolar disorder (BPD) is a debilitating heritable psychiatric disorder. Contemporary rodent models for the manic pole of BPD have pr …
Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli.
Dannlowski U, Kugel H, Franke F, Stuhrmann A, Hohoff C, Zwanzger P, Lenzen T, Grotegerd D, Suslow T, Arolt V, Heindel W, Domschke K. Dannlowski U, et al. Neuropsychopharmacology. 2011 Aug;36(9):1879-85. doi: 10.1038/npp.2011.73. Epub 2011 Apr 27. Neuropsychopharmacology. 2011. PMID: 21525857 Free PMC article.
Recent studies point to a role of neuropeptide-S (NPS) in the etiology of anxiety disorders. In animal models, NPS and its receptor (NPSR) were shown to be highly expressed in the amygdala, a central structure in the fear circuit, also known to be hyper-responsive i …
Recent studies point to a role of neuropeptide-S (NPS) in the etiology of anxiety disorders. In animal models, NPS and its rec …
Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders.
Leonard SK, Dwyer JM, Sukoff Rizzo SJ, Platt B, Logue SF, Neal SJ, Malberg JE, Beyer CE, Schechter LE, Rosenzweig-Lipson S, Ring RH. Leonard SK, et al. Psychopharmacology (Berl). 2008 May;197(4):601-11. doi: 10.1007/s00213-008-1080-4. Epub 2008 Mar 3. Psychopharmacology (Berl). 2008. PMID: 18311561
OBJECTIVES: To extend the characterization of NPS, the present studies examined the in vitro pharmacology of mouse NPSR and the in vivo pharmacology of NPS in three preclinical mouse models predictive of anxiolytic action: the four-plate test (FPT), elevated zero maze (EZM …
OBJECTIVES: To extend the characterization of NPS, the present studies examined the in vitro pharmacology of mouse NPSR and the in vivo phar …